l-Chicoric acid
l-Chicoric acid
CAS: 6537-80-0;70831-56-0
Molecular Formula: C22H18O12
l-Chicoric acid - Names and Identifiers
l-Chicoric acid - Physico-chemical Properties
| Molecular Formula | C22H18O12 |
| Molar Mass | 474.37 |
| Density | 1.641±0.06 g/cm3(Predicted) |
| Melting Point | 200～208℃ |
| Boling Point | 785.0±60.0 °C(Predicted) |
| Specific Rotation(α) | (c, 1.7 in MeOH)-384 |
| Flash Point | 272.9°C |
| Solubility | Soluble in methanol |
| Vapor Presure | 5.86E-26mmHg at 25°C |
| Appearance | White powder |
| Color | Pale Yellow |
| pKa | 1.47±0.25(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| Stability | Hygroscopic |
| Refractive Index | 1.726 |
| MDL | MFCD22683653 |
l-Chicoric acid - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R42/43 - May cause sensitization by inhalation and skin contact. |
| Safety Description | S22 - Do not breathe dust. S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| WGK Germany | 3 |
| HS Code | 29182900 |
l-Chicoric acid - Reference
| Reference Show more | 1. [IF=11.878] Li Xinming et al."A fast and specific fluorescent probe for thioredoxin reductase that works via disulphide bond cleavage."Nat Commun. 2019 Jun;10(1):1-12 |
l-Chicoric acid - Reference Information
| Plant Source: | Echinacea purpurea |
| chicory extract | , enhances immune function and induces apoptosis, and inhibits hyaluronidase, protecting collagen from free radicals that can lead to degradation.|
| source plant | [base source] Dried roots, stems, leaves and flowers of chicory. [plant morphology] perennial herb, 40-120 in height, with gray-white plant. Root hypertrophy. Stem upright, borated, hollow, branches oblique and apex thick, with sparse coarse or sericeous hairs, rarely hairless. Basal leaves and lower leaves of stem divided obfeasibly to the whole, 5-11cm in length and 1-2cm in width. The Apex lobes were larger, the lateral lobes were triangular, the base was tapering into a winglet; cauline leaves sessile, leaf blade progressively smaller, few, aciculate-ovoid-to-linear, upper leaves small, entire, lower part of all leaves sparsely coarse or sericeous. Solitary stems and branch ends of capitulum, or 2-3 in the upper axillary clusters; Involucre cylindrical, 8-14mm in length; Outer involucre pieces varying in length and short shape, the lower part was soft-leathery, with eyelashes, outside hairless or hairy; Flowers all ligulate, flowers blue. Achene apex truncate, Crown short, scaly, Apex dentate split. Flowering 7-8 months, fruit 9 months. [Habitat and distribution] it was found in the wetland at the foot of the mountain and the Desert Mountain at the coast. Produced in Shenyang, Dalian and other cities. Figure 1 is chicory |
| extraction method | The traditional extraction process of cichoric acid is hot reflux extraction, and the extraction rate of cichoric acid is not high; at the same time, the traditional extraction method will also cause damage to the heat sensitive active ingredients, which is not conducive to the extraction of cichoric acid. In recent years, the research scope of supercritical CO2 fluid extraction technology involves natural products, food, spices, medicine, chemical industry, environmental protection and other fields, and has made a series of progress. The yield of dry extract produced by traditional extraction process is low, the content of cichoric acid is low, and the quality fluctuation is large. The yield of dry extract produced by supercritical carbon dioxide extraction process is much higher, and the quality is stable. The optimum conditions were as follows: extraction pressure 30MPa, extraction Time 2h, extraction temperature 60 ℃, CO2 flow rate 25kg · h-1, by adding 10ml · g-1 of 40% ethanol as the entrainer to extract cichoric acid, it has the advantages of high extraction rate, good product purity and simple process. weigh 100g of echinacea powder (60 mesh), place it in the extraction cylinder, add a certain amount of entrainer according to the process conditions of experimental design requirements, set the extraction pressure, extraction temperature, extraction time, CO2 flow rate, the echinacea powder is subjected to supercritical carbon dioxide extraction, and the carbon dioxide gas flowing out from the upper part of the extraction cylinder is separated under reduced pressure to obtain the extract. After filtration, the extract is concentrated in vacuum to obtain a dry extract. |
| pharmacological effects | Recent pharmacological studies in the United States and European countries have shown that cichoric acid has immune enhancement and anti-inflammatory effects, it can inhibit hyaluronidase and protect collagen III from free radicals that can lead to degradation. Recent studies have also shown that cichoric acid has HIV-1 and HIV-1 inhibition of integrase. |
| stability | 1, the effect of pH value on the stability of cichoric acid The effect of different pH values on the stability of cichoric acid is quite different. The degradation rate of cichoric acid in strong acidic environment is lower than that in weak alkaline environment. 2. Effect of temperature on stability high temperature leads to accelerated degradation of cichoric acid, and low temperature is beneficial to the stability of cichoric acid. 3. Effect of metal ions on stability Na and K do not react with cichoric acid; However, cichoric acid reacts very quickly with CaCl2 solution, and the mechanism of solution yellowing remains to be further explored. The complexity of the food system leads to a variety of metal ion mixing, Ca2 and other metal ions may have a greater impact on cichoric acid. When cichoric acid is applied to food, the effect of metal ions in the liquid food environment or the environment after brewing should be considered, avoid the degradation of cichoric acid and the change of food quality caused by reaction. 4. Effect of ultraviolet rays on the stability of cichoric acid cichoric acid in methanol is more easily isomerized into meso-cichoric acid under the influence of ultraviolet rays, and because the polarity of methanol is smaller than that of water, the isomeric conversion rate of cichoric acid was higher. When cichoric acid is applied to food, it should be considered that the sensitivity of cichoric acid to ultraviolet rays after dissolution is higher, and the contact with ultraviolet rays should be reduced in the process. 5. Study on stability in fruit juice beverage low temperature storage is more conducive to the stability of cichoric acid than room temperature; And cichoric acid in aqueous solution at room temperature (25 ℃) is basically completely decomposed after 15 days, this indicates that the beverage system can protect cichoric acid from degradation to some extent. Fruit juice beverage system itself is very complex, and the beverage indicated in the 445mL system added 100 mg of vitamin C, with antioxidant effect, can play a certain degree of protective effect on cichoric acid, thus the concentration of cichoric acid is still at a high level even after 3 months of standing. 6. Study on the stability of milk powder milk powder as a representative solid food environment, each component in the water activity is very small, isolated air water vapor, protected from light environment is relatively stable, lack of environmental factors leading to the degradation of cichoric acid, thus the concentration of cichoric acid is not affected by time and milk powder system, and it is stored under dry and closed conditions at room temperature, cichoric acid in milk powder system can maintain relatively stable. 7. Study on the stability of jelly The jelly system itself is very stable, and its water activity is very small. Cichoric acid is stored under such a relatively closed condition, isolation of oxygen and water vapor, can be maintained for a long period of time. The slight fluctuation of the detection data may be caused by the error of the sample processing. |
| biological activity | Cichoric Acid is a natural compound with antioxidant activity. |
Last Update：2024-04-09 20:45:29
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